By “media”, I’m going to go with an established setting…I’ve got a tie.
If we’re going with books, it’s hands-down the Gaea Series by John Varley — Titan, Wizard, and Demon, which have some of the most inventive worldbuilding in a sci-fi setting. If you haven’t read them, you really should give them a try. The style of each book is different — a fast-paced action/adventure in a strange, sentient world; a subversive spy/action adventure in the same, but which really develops the Titanides; and the “what the f#$% were you smoking finale between this world, Gaea, and the heroes.
If TV/movies, I’d like to see a game based on Defiance, which was a bit weak in beginning the first season, but rapidly improved.
I do think a nice dystopian game could be built around the comic book world of Lazarus by the talented Greg Rucka (read his Queen & Country series — it’s fantastic!)
The Black Campbell 
9 August, 2015 at 12:30
I completely agree with Defiance being developed into some sort of RPG. There’s enough meat there and it’s different enough, that I think it would do well.
One other that I’ll add, is that I wish someone would develop BSG with something other than Cortex as the system. My players absolutely despised it the last time we played and when it came to trying to quantify the ships, there just wasn’t enough detail. It could be due to the backgrounds of the players as most of us started in the late 70s/early 80s with Traveller (and it’s successors), FASA’s Star Trek, and a couple others that clearly defined and built the ships…Personally, I don’t mind characters being a little cinematic, but extending it to ships was where it fell apart for me.